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Meanwhile, humanized 3D organ-on-a-chip models and brain organoids are dismantling species barriers, recapitulating the neurovascular unit with human cells to decode MRIS in a clinically relevant milieu [250, 251]

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Studies have shown that IL-1 and NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation is crucial in inhibiting viral replication via maintenance of optimal interferon and immune response [34, 35]