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Increased glucose partitioning to serine following SAAR is abolished by loss of hepatic PSAT1 Next, we aimed to further connect the attenuated improvement in glucose tolerance observed in liver PSAT1 KO mice fed a HF-SAAR diet to inability of hepatocytes to synthesize serine from glucose (Fig

Endoplasmic reticulum protein BI-1 regulates Ca 2+ -mediated bioenergetics to promote autophagy

A novel prodrug of a -glutamylcyclotransferase inhibitor suppresses cancer cell proliferation in vitro and inhibits tumor growth in a xenograft mouse model of prostate cancer

doi: 10.1210/endo.140.8.6918 271 BilezikjianLMValeWW

Results Identification of GSH as a signaling molecule that activates long-distance plant defense signaling events During the genetic screening of the rolling circle amplification-mediated hairpin RNA (RMHR)-based Arabidopsis library 19,20 for mutants with altered defense response to a disastrous plant fungal pathogen Botrytis cinerea ( B