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Although novel treatments have improved patient survival in melanoma, the overall prognosis remains poor

While the classical dichotomy of microglial polarization into M1/M2 states is now recognized as overly simplistic, HMC3 cells express markers associated with both pro-inflammatory (M1-like: CD40, CD86) and anti-inflammatory/reparative (M2-like: CD163, CD206) activation states

Table 3 Characteristics of six cases with IGF1 defects

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy