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The generation of ROS via the Fenton reaction, catalyzed by excess labile iron, is a well-established mechanism for inducing cellular damage, including DNA damage [96]

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Studies are focusing on how these exposures interact with genetic factors to affect cancer development, such as multiple metabolic reprogramming and increased susceptibility to breast cancer

One proposed mechanism of decreased folate in psoriasis may associated with inflammatory changes in intestinal mucosa, which causes reduced absorption of dietary folate [10]