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Cancer 88 , 951956 (2003)

The mechanisms of NPTAs in AD treatment include the following four key aspects: Initially, the localized thermal effects during PTT improve the permeability of the BBB, facilitating drug transport across the BBB and enhancing drug accumulation in brain lesions

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generated mice overexpressing human catalase targeted to the peroxisome (PCAT), nucleus (NCAT), or mitochondria (MCAT) and found that overexpression of catalase in the mitochondria extended both median and maximum life span in both males and females, while overexpression of catalase in the nuclei did not show a significant extension of median nor maximum life span (Schriner et al