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Exercise caused almost a 25% increase in activity in the GK rat tissues

While the evidence is still not enough to warrant the clinical use of sildenafil (or any other PDE5i) for the treatment of diabetic heart kinetics or as a first-line treatment for other CV complications in such patients, this new avenue of research looks promising, and new trials will hopefully allow the drafting of guidelines for clinical practice

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The Phase 2 liver data showing 82% fat reduction provides strong rationale, but the Phase 3 endpoints are more demanding

In these cases, pharmacists should be ready to recommend alternative drugs to the prescribing physician