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According to guideline, it is advised that the daily dose of PN should not exceed 200300 mg in order to prevent PN overdose, which can lead to nerve damage and motor dysfunction [13, 15]

Tjioe, D.M

10.1089/ars.2010.3821 45 HeY

The commenter suggested that CMS establish a grace period wherein, if a manufacturer timely submits a Suggestion of Error and does not pay the rebate amount then CMS would not assess a CMP on that rebate amount until after the reconciliation process, at which time CMS would make a final determination on the Suggestion of Error

In humans, high doses of paracetamol can cause hepatotoxicity and sometimes nephrotoxicity