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doi: 10.1007/s12011-021-03084-4

Resistance to 5-FU has been associated with increased dependence on L-serine, either through SSP upregulation or enhanced serine uptake

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Thirty-two (91%) RCTs were performed in the metastatic or locally advanced stage, whereas only three (9%) trials were conducted on neoadjuvant or adjuvant settings [34]