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Description

According to the NHS, a long-term deficiency in the vitamin can lead to vitamin B12 anaemia - a shortage of red blood cells

The mutation in ALDH4A1 leads to the accumulation of pyrroline-5-carboxylate (P5C) in the mitochondria, which can react with PLP to cause PLP deficiency in the brain and can also be converted to proline, resulting in elevated plasma proline levels (Fig