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Although there are some secondary biomarkers such as the measurement of certain enzyme activities in the leukocytes or the excretion of 3-hydroxy-3-methylbutyric acid in the urine, these are ambiguous indications and only a few doctors are familiar with the corresponding tests (8, 9)

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Categorizing patients into decade-based groups allows for a more systematic comparison and analysis across different age ranges, which is a commonly used approach in similar studies 20

The associations were strongest for liver, lung, pancreatic cancers, and myeloid malignancies