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doi: 10.1016/j.exer.2010.06.009 164 TorrigliaAZigmanS

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It has been demonstrated that the cAMP response element regulator (CREM) could induce the ICER isoform to promote Th17-cell differentiation, which also enhanced the expression of GLS1, the first enzyme in the Gln catabolic pathway, so that inhibition of GLS1 could improve Th17 differentiation in vitro and in mouse EAE (47)