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Importantly, plasma GHK levels decline dramatically with age (from 200 ng/mL at age 2080 ng/mL at age 60), directly correlating with decreased skin repair capacity and accelerated visible aging (Pickart and Margolina, 2018

The high proline content (4 of 15 residues, including a triple Pro-Pro-Pro stretch at positions 3 to 5) gives BPC-157 unusually good resistance to gastric and intestinal proteases, which is why some published animal work uses oral administration

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