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Simultaneously, growth hormone and IGF-1 stimulate lipolysis in adipose tissue through activation of hormone-sensitive lipase and inhibition of acetyl-CoA carboxylase, enzymes that control fat mobilization and utilization

Adipocyte specific KO of ABHD5 decreased lipolysis, resulting in reduced FA flux to the liver, and protection against HFD induced hepatic steatosis (149), suggesting that suppressing adipocyte lipolysis could be protective against FLD

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