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In summary, PCBPs may provide strategies for the efficient management of the newly acquired or mobilized iron atoms by efficiently delivering them to their appropriate destination, particularly in cell types that routinely encounter dynamic changes in the cytosolic LIP

Positions in the sequence with high attention give more weight to the final prediction of the model

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While direct experimental evidence comparing the responsiveness of specific -cell subpopulations to SCFAs, GLP-1, or other microbiota-derived metabolites remains limited, existing resources such as HPAP (Kaestner et al., 2019), reveal clear associations between -cell maturity, chromatin accessibility, metabolic state, and the capacity to sense exogenous signals