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Hyperactivity of the HPA axis is thought to be an important pathophysiological mechanism underlying depression

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We speculate that Set7/9-mediated methylation of FOXO3 may also have a dual effect on the expression of its target genes, especially because p300/CBP and Set7/9 compete for the same target K271 lysine residue for acetylation and methylation, respectively

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In patients and mice with acute myeloid leukemia (AML), the normal intestinal microbiome is severely perturbed [110]