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Moreover, intracellular ammonia overload appears to downregulate RUNX2 by promoting ROS accumulation (176178) ( Figure 5A )

Bagnis, A., Izzotti, A., Centofanti, M

Chen L, Hambright WS, Na R, Ran Q

For example, if a candidate dsRNA is observed to decrease protein or mRNA levels by at least 20%, 30%, 40%, 50%, or more, then the agent can be considered for a clinical trial