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Conclusions and future directions Ferroptosis, a distinct form of iron-dependent cell death driven by lipid peroxidation, has emerged as a key pathological mechanism underlying multiple cognitive disorders, including AD, PD and DACI

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It is also reported that the 17-hydroxysteroid dehydrogenases HSD17B1, HSD17B5, and HSD17B7 catalyze the C3 hydroxy oxidation ( FIGURE 7 The double-bond isomerization following 3-hydroxy oxidation in the steroids is conventionally ascribed to an ancillary function of the dehydrogenase, displaying 3-ketosteroid isomerase activity in addition to the redox catalysis

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Kamath, R

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J Biol Chem 2005

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