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Association of chorioamnionitis with bronchopulmonary dysplasia among preterm infants: a systematic review, meta-analysis, and metaregression

Lactate subsequently triggers histone lactylation, especially H4K8/12la, as well as H3K18la, enhancing paired-box gene 6 (PAX6) expression, which in turn inhibits IDH3, creating a feedback loop of IDH3-lactate-PAX6-IDH3 that worsens AD progression

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In conclusion, the FRGs classification is tightly correlated with TME 4 subtypes

Doctors may choose this route when the goal is to bring the therapy closer to the central nervous system , potentially increasing local exposure