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This allows the brain to maintain a very low extracellular L-glu concentration in the low micromolar range (Baker et al., The role of extrasynaptic glutamate in the brain Apart from the role of L-glu as the principal excitatory neurotransmitter released from glutamatergic presynapses as described above, it has become apparent that L-glu receptors outside the synaptic cleft also play an important role in brain physiology (Papouin and Oliet, 2014)

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Pegaptanib sodium was the first anti-VEGF drug approved by the FDA to treat wet AMD, but this drug has largely been replaced with improved alternatives like bevacizumab, ranibizumab, and aflibercept due to better results shown in various trials

Haghikia A, Schett G, Mougiakakos D

The dosage was based on the national and WHO guidelines [,]