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The animal study was approved by the Ethics Committee of Changzhi Medical College (number: DW2023051)

The results have invited our speculation, whether intake of exogenous DHA also relieves pain in RA

Funding This study was funded by Public Welfare Technology Research Program/Social Development Project of Zhejiang Province (Grant LGF22H030011), the Key Research and Development Program of Zhejiang Province (Grant 2021 C03120), and the Wenzhou Basic Scientific Research Projects (Grant Y2023415)

This study focused on the in vitro evaluation of four novel prodrug esters: the R- and S- chiral esters of 4-[(nitrooxy)methyl]phenyl N-acetylalaninate (R- and S-NPAA) and the R- and S- chiral esters of 4-[(nitrooxy)methyl]naphth-1-yl N-acetylalaninate (R- and S-NQM), which are activated, to varying extents, by oxidized protein hydrolase (OPH, EC 3.4.19.1) yielding a quinone methide (QM) intermediate capable of depleting glutathione (GSH), a key intracellular antioxidant

16 Given eflornithines unique mechanism of action, its combination with more traditional antiandrogenic type medications may be reasonable for management of hirsutism