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The G6P can be recycled into the oxidative reactions of the PPP, generating more NADPH

4 Interestingly, neurocognitive decline in schizophrenia is seen before other symptoms arise in neuropsychiatric disorders and proceeds following the onset of illness

Notably, Musicki and colleagues demonstrated that O-GlcNAcylation of eNOS at Ser-1177 prevents its activation by shear stress and VEGF signaling, highlighting a direct mechanistic link between PTM dysregulation and penile vascular dysfunction[54]