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These results suggested that GGT was the most important enzyme responsible for GSH degradation and that deletion of both ggt and pepT could significantly suppress the GSH degradation

Many of these are involved in amino acid metabolism, nucleotide metabolism, and energy-related pathways, further supporting the notion of a time-dependent global metabolic downshift in control neurospheres

& Verkoelen, C

Cellular Health: Glutathione is crucial for maintaining healthy cells

To fully abrogate any possible RBR-residing catalytic activity of ANKIB1, we next expressed mutant ANKIB1 lacking the entire RBR (ANKIB1RBR) in ANKIB1-KO cells (Extended Data Fig