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En 2018, une revue Cochrane [ 11 ] a montr que l a supplmentation par voie orale est tout aussi efficace et suffisante pour prvenir un dficit (malgr un niveau dvidence plutt faible, principalement cause du petit nombre dtudes et de patients)

If the depressed oxygen consumption caused by NNMT overexpression indicates the depression of aerobic metabolism, the regulatory effect of NNMT on anaerobic metabolism might be reversed