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Because it was extremely difficult to immobilize IL-1 on the sensor chip, the interaction between KCF18 and IL-1 was not measured through SPR detection but was confirmed through cellular assays and the animal model

Even more fascinating, the authors then injected into normal mice one of the molecules that was markedly elevated in the blood when the mice had a leaky guta metabolite known as 4-ethylphenylsulfate (4-EPS)