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It achieves this by activating protein kinase B (Akt) to reduce the activity of glycogen synthase kinase-3 beta (Gsk3), reducing the activity of a critical protective protein, nuclear factor-like 2 (Nrf2) (75)

[DOI] [PubMed] [Google Scholar] 2.Vallee B.L., Falchuk K.H

P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation