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Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

This section systematically examines the core mechanistic alterations in carbohydrate, lipid, and amino acid metabolism, which collectively establish the pathological foundation for the subsequent development of multi-organ complications

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However, the dose of polyphenols alone is not a crucial factor when considering the toxic potential of phenolic compounds, as it also depends on the time of exposure and possible synergistic effects

The charged nature of GSH (negative at physiological pH) suggests that GSH cannot passively diffuse into the mitochondria, because the mitochondrial matrix has a negative potential relative to the cytoplasm