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These mechanisms encompass modulation of gut microbiota, reduction of inflammation, and improvement of metabolic parameters ( Table 2 )

It was reported that metabolic activation of numerous other flavonoids was involved in or aggravated their toxicities (Table 1)

Immune balance is another important benefit

These variations are concentrated in genes related to protein synthesis, mitochondrial function, and virulence factors like HSP78 and sterol 24-C-methyltransferase, along with CNVs affecting mitochondrial transport, vesicular trafficking, and protein turnover (Shaw et al., 2019