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Maintenance of the mucus layer is very important bacteria must be kept away from the colonic epithelium, otherwise an immune response may be activated, leading to inflammation (11, 12)

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In a phase 3, double-blind placebo-controlled multicenter trial (n=94), participants with a history of recurrent AHP attacks (2 in the 6 months before enrollment) givosiran (2.5 mg / kg monthly) treatment resulted in a 73% reduction in mean annualized attack rate compared with placebo treatment

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With consistent use over time, there can be additional benefits of using a CLA supplement

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