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doi: 10.1038/gim.2014.208 98 PorsteinssonA

qRT-PCR analysis revealed that treatment with K-Hcy-modified recombinant HMGB1/2 significantly upregulated both SASP markers and MARS1 expression in HCMECs, suggesting a potential HMGB1/2 K-Hcy -MARS1-driven positive feedback loop and an intensified paracrine senescence signaling cascade (Figure 6C-D)