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Magnetic resonance imaging showed that iron deposition is correlated with cognitive impairment, and this deposition is mainly observed in the hippocampus, cortex, and basal ganglia, where brain cells experience oxidative stress, lipid peroxidation, and increased cystine/Glu transporter expression, iron metabolism, and balance (Masaldan et al., 2019)

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Metabolic reprogramming in astrocytes distinguishes region-specific neuronal susceptibility in Huntington mice