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It plays a crucial role in the livers detoxification processes

245,246 Hence, GLP-1 activates -cells and promotes somatostatin secretion, forming a multi-layered inhibitory mechanism that effectively reduces glucagon secretion

Under oxidative stress, the transcription factor Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2) translocates from the cytoplasm into the nucleus and binds to the antioxidant response element (ARE)