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doi:10.1016/j.ymben.2003.09.001

Highlights B 1 R promotes adipose inflammation, making it a promising anti-obesity target

Zubrow, M

In the hypoxic, inflammatory and hyperlipidemic milieu of the atherosclerotic plaque riddled with oxidative stress, metabolism shifts to increase anaerobic glycolysis, the pentose-phosphate pathway and amino acid use

Upon reaching the target site, the linker undergoes hydrolysis, reduction, oxidation, or rearrangement triggered by the local chemical environment, releasing the active drug molecules