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continue vitamin supplementation during treatment and for 21 days after the last dose of Pemetrexed Injection to reduce the severity of hematologic and gastrointestinal toxicity of Pemetrexed Injection [see Dosage and Administration (2.4)]

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The ACTH(4-7) fragment, Met-Glu-His-Phe, is responsible for the neurotropic properties described in animal model studies, while lacking the corticotropic activity that requires amino acid residues 1-3 present in full-length ACTH