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Moreover, cGAS is no longer autophagically degraded and can recognize micronuclei generated by mitotic defects, thereby inducing cGAS-STING signaling (269)

Di Cesare M, Perel P, Taylor S, Kabudula C, Bixby H, Gaziano TA, McGhie DV, Mwangi J, Pervan B, Narula J, Pineiro D, Pinto FJ

The involvement of DNA-damage and -Repair defects in neurological dysfunction

Mechanistically, detoxification of peroxides by mammalian GPx-1 proceeds by way of a bi-substrate ping-pong-type enzymatic mechanism in which saturation kinetics are not observed