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Bone metastases are a common complication of lung cancer and result in the release of ALP into the bloodstream due to the breakdown of bone tissue (38)

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DM4 is not recognized by any of the main medical classification systems, including the ADA, WHO and ICD However, DM4 is used informally in new scientific publications to refer to a rare form of insulin resistance (IR) In 2022, researchers Ronald Evans and Ye Zheng, who study IR in old age, proposed the name type 4 diabetes [12] for IR that occurs in lean elderly patients without autoimmune diabetes and/or obesity DM4 is estimated to be present in 20% of patients who are newly diagnosed with diabetes and aged over 65 years, amounting to 2 million patients in the US [12]

Biochem Biophys Res Commun 344:13521359 Teichert J, Preiss R (2002) High-performance liquid chromatographic assay for alpha-lipoic acid and five of its metabolites in human plasma and urine

Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review