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NHS Guidance on Safe Calorie Reduction and Heart Health The NHS recommends a deficit of around 600 kcal per day for safe weight loss of 0.51 kg per week, advising against very low calorie diets below 800 kcal/day unless medically supervised

It also provides essential data for improving medical understanding

Carcinogenesis, Mutagenesis, Impairment of Fertility Long term studies in animals to evaluate carcinogenic potential have not been done

In obese rodent models, it promotes lipolysis by breaking down stored fats into free fatty acids without stimulating GH pathways such as IGF-1

When someone is experiencing an urgent care situation and cannot make it in to see their primary care provider in a timely manner, they can instead choose to visit their local urgent family clinic