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Additionally, KYN produced by IDO is an endogenous ligand of aromatic hydrocarbon receptor (AhR)

Quantification of the synergy using multidimensional synergy of combinations (MuSyC) 37 technique for AXT050 and sorafenib at steady state suggest an inconsequential synergistic efficacy ( obs = 0.001 and 0.035 for pAkt and pERK, respectively), as well as a negligible antagonistic potency (log( 2 ) = 0.02 and 0.05 for pAkt and pERK, respectively)