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Notably, when a higher cutoff value for elevated serum folate was used in this study (60 nmol/L), the OR associated with high folatelow vitamin B-12 increased in magnitude [2.46 (0.90, 6.71)], although it did not reach statistical significance likely because the sample size of participants with cognitive impairment was only n = 7 (23)

This hypothesis is supported by several studies that have shown supplementation with SAM improves depressive symptoms (104-107)

If youre experiencing fatigue, weakness, or difficulty concentrating, B12 shots may be a helpful solution

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Based on evidence from clinical studies, the USPHS, AAP, and ACOG recommend a folic acid intake of 0.4 mg/day PO from food and/or supplements in females during the child-bearing years, and 0.6 mg PO daily throughout pregnancy