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Although it is effective in targeting cancer cells, it can alter many other tissues like CNS and GI tissue (Bai et al., 2021)

Tetramethylpyrazine (TMP), an active component in both CHF and the medicinal herbs Ligusticum wallichii (Chuanxiong) , has the potential to prevent AKI via a variety of processes, including ameliorating oxidative stress damage, suppressing inflammatory responses, deterring apoptotic cell death of intrinsic renal cells, and modulating autophagy (Gong, 2018

Blankfield A

In other words, they block androgen receptors without actually activating them

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