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Moreover, the advent of single-cell RNA sequencing technology has enabled researchers to investigate gene expression heterogeneity at the single-cell level, providing a novel perspective on cellular differences and their roles in disease [264, 270]

Management with TCM for ME/CFS TCM has been increasingly explored as an alternative approach to managing ME/CFS [176]

On the host side, transcriptional profiling showed high activity of pattern recognition receptors and expanded gene families involved in innate immunity and lysosomal enzymes