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Inflammation is also involved, causing the accumulation of plaques and tangles to have even more damaging effects

This reduction in elasticity can also extend to the skin around your eyes and mouth, making those areas appear more tired and aged

Marsh, T

Of course, treatable conditions such as immune-mediated ataxias (gluten-related ataxia, anti-GAD-antibodies-associated ataxia, systemic lupus erythematosus, Sjgrens syndrome) [ 62 , 63 ], or metal storage disorders such as Wilsons disease [ 64 ], which may have an insidious onset, should be ruled out in the early stages of the diagnostic process