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We considered these requests in development of the CY 2025 PFS proposed rule, but we do not believe it necessary to provide further information to fulfill CMS' statutory obligation and believe that the potential benefit to manufacturers of additional data is outweighed by the administrative burdens additional reporting will impose to the agency

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In addition, the concentration of cyanocobalamin is detectable in plasma only in smokers due to the increased cyanide exposure of cigarette smoke in combination with the dietary supplement (Domke et al., 2004)

However, we continue to believe practitioners have access to this information when verifying a patient's Medicare eligibility