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2014 May;50(5):356-361

Two patterns I see clinically: The form of B12 matters

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B3 that is not methylated can be instead transformed into another molecule called nicotinamide adenine dinucleotide (NAD+), which is essential for producing energy, repairing DNA, and other benefits

PMC2431115 Subcutaneous injection pain and local-reaction factors - Needle geometry, injection depth, volume, speed, pH, and tonicity can influence pain and local reactions after SubQ administration