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4.1 Initiation stage of inflammation: Intrinsic immune recognition of MSU and dual-signal inflammasome activation The immune response induced by MSU follows the double signal model. First, toll-like receptors TLR2 and TLR4 recognize the crystal structure and recruit the intracellular adaptor protein myeloid differentiation primary response protein 88 (MyD88)

In addition, epithelial polysaccharides serve a decisive role in shaping gut microbiota by providing binding ligands and nutritional substrates, thereby influencing microbial composition and colonization

Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47 phox expression and evidence of endothelial oxidative stress

An overview of selenium uptake, metabolism, and toxicity in plants

The incidence showed minimal change over time at 24 kHz, suggesting that this frequency may reflect a consistent deficit in the animals