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Crucially, this study noted that patients with lower B12 levels exhibited significantly worse clinical progression and higher markers of systemic inflammation

Additionally, the activity of tau kinase, which causes tau hyperphosphorylation, and the amount of pTau protein were increased

The findings indicated that radiation long, term altered the overall gut microbial composition, therefore, favouring harmful species such as Erysipelotrichaceae and Akkermansia muciniphila while decreasing beneficial bacteria such as Firmicutes and Actinobacteria

Chou S, Wang H, Taniguchi A, Bucala R

The other main roles of arhalofenate are to activate AMPK, inhibit NF-B and NLRP3 inflammasomes to promote the polarisation of anti-inflammatory macrophages, as well as significantly reduce UA-induced inflammation (Salminen et al., 2011