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doi: 10.1038/nrg3230 100 JungM.PfeiferG

The majority of individuals infected with Mtb mount an adequate innate immune response which results in early clearance of the bacteria

Thus, we anticipated that by utilizing the CCW16 warhead, degraders of RNF4 could be designed by linking this cysteine-reactive moiety to established E3 ligase ligands or to itself (homo-PROTACs) (Diehl et al, 2024)

If symptoms spread beyond the site or breathing is affected, seek emergency care immediately