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10.1016/j.aquatox.2012.03.007 210 VoisinA

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Both perform best when they get their own time slot

ATP7A facilitates the efflux of Cu+ from the intestinal epithelium into the circulation whereas ATP7B stores excess Cu+ in intracellular vesicles to maintain normal homeostasis (31)

Mitochondria-targeted probes (e.g., MitoSOX) can track mitochondrial O 2 trends but are susceptible to photobleaching, redox cycling and DNA intercalation, so interpret only with HPLC verification, strict light management and matched membrane-potential conditions (Zhao et al