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Because the mitochondrial leader peptide is cleaved off after import into mitochondria, c-GPx4 and m-GPx4 cannot be distinguished on the protein level anymore

To this end, humanized transgenic ( htg ) UGT1A wild type (WT) and htgUGT1A -SNP mice, containing a human haplotype of 10 common occurring UGT1A SNPs, were used

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As methionine is the only precursor of cysteine in a cysteine-free diet, and cysteine is one of the three amino acids comprising glutathione, MR might logically be expected to reduce, rather than increase, glutathione levels