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CPTAC proteomic data analysis For proteomic analysis of human brain and GBM tissues, raw phosphoproteome and proteome mass spectra converted to .mzML open standard format from the Clinical Proteomic Tumour Analysis Consortium (CPTAC) GBM discovery cohort were downloaded from the Proteomic Data Commons ( study IDs PDC000204 and PDC000205, RRID: SCR_018273)