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Alamin A, Gupta V

Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus

They catalyzed the conjugation of intracellular glutathione with great varieties of chemicals possessing electrophilic centre and the final GSH-conjugates had increased hydrophilicity which facilitate their further metabolism and elimination

This susceptibility of complex I to OS might be explicated by the oxidation of thiol (SH) groups of protein and the existence of accessible oxidation sensitive iron-sulfur centers in this complex [74]